The American Heartworm Society recommends year-round administration of medications approved by the US Food and Drug Administration (FDA) to prevent heartworm infection in dogs, cats and ferrets. Currently available preventives are listed below; as new products become available, updates will be posted at heartwormsociety.org. Consult the appropriate manufacturer for minimum age/weight, use during breeding/lactation, or other health requirements for product usage.
Scroll down for feline and ferret preventives.
Canine Preventives
The American Heartworm Society recommends year-round administration of medications approved by the US Food and Drug Administration (FDA) to prevent heartworm infection. Currently available preventives are listed below; as new products become available, updates will be posted at heartwormsociety.org. Consult the appropriate manufacturer for minimum age/weight, use during breeding/lactation, or other health requirements for product usage.
Scroll down for feline and ferret preventives.
PREVENTIVES FOR DOGS | Dirofilaria immitis | Other Parasites Treated in Addition to Heartworm | ||||||||||
Tissue Stages (Larvae) | Circulating Microfilariae | Fleas | Ticks | Hookworms | Roundworms | Whipworms | Tapeworms | Ear Mites | Sarcoptic Mange Mites | |||
Drug | Trade Name(s) | |||||||||||
Oral Administration (monthly tablets and chews) | ||||||||||||
Ivermectin | HEARTGARD® (Boehringer Ingelheim) | X |
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Ivermectin + pyrantel pamoate | HEARTGARD® Plus (Boehringer Ingelheim) | X |
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| Xa | Xb |
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Iverhart Plus® (Virbac) | X |
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| Xa | Xb |
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Tri-Heart® Plus (Merck) | X |
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| Xa | Xb |
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Ivermectin + pyrantel pamoate + praziquantel | Iverhart Max® (Virbac) | X |
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| Xa | Xb |
| Xh |
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Milbemycin oxime | Interceptor® (Elanco), MilbeGuard® (Ceva) | X |
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| Xc | Xb | Xd |
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Milbemycin oxime + praziquantel | Interceptor® Plus (Elanco) | X |
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| Xc | Xb | Xd | Xf |
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Milbemycin oxime + lufenuron | Sentinel® (Merck) | X |
| Xj |
| Xc | Xb | Xd |
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Milbemycin oxime + lufenuron + praziquantel | Sentinel® Spectrum® (Merck) | X |
| Xk |
| Xc | Xb | Xd | Xf |
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Milbemycin oxime + spinosad | Trifexis® (Elanco) | X |
| Xo |
| Xc | Xb | Xd |
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Moxidectin + sarolaner + pyrantel pamoate | Simparica® Trio (Zoetis) | X |
| Xl | Xm | Xn | Xb |
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Injectable Administration (every 6 or 12 months) | ||||||||||||
Moxidectin | ProHeart® 6 (Zoetis), ProHeart® 12 (Zoetis) | X |
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| Xp |
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Topical Administration (monthly spot-on) | ||||||||||||
Moxidectin + imidacloprid | Advantage Multi® (Elanco), IMOXI™ (Vetoquinol USA) | X | X | Xo |
| Xq | Xr | Xd |
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| Xs | |
Selamectin | Revolution® (Zoetis), Paradyne® (Zoetis), Senergy™ (Virbac), Selarid™ (Norbrook), Revolt™ (Aurora) | X |
| X1 | X2 |
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| Xv | Xs | |
PREVENTIVES FOR CATS | Dirofilaria immitis | Other Parasites Treated in Addition to Heartworm | ||||||||||
Tissue Stages (Larvae) | Circulating Microfilariae | Fleas | Ticks | Hookworms | Roundworms | Tapeworms | Ear Mites | |||||
Drug | Trade Name(s) | |||||||||||
Oral Administration (monthly tablets and chews) | ||||||||||||
Ivermectin | HEARTGARD® (Boehringer Ingelheim) | X |
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| Xg |
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Milbemycin oxime | Interceptor® (Elanco), MilbeGuard (Ceva) | X |
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| Xc | Xe |
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Topical Administrations (monthly spot-on; Bravecto PLUS is every 2 months) | ||||||||||||
Moxidectin + imidacloprid | Advantage Multi® (Elanco), IMOXI™ (Vetoquinol USA) | X |
| Xo |
| Xt | Xu |
| Xv | |||
Moxidectin + fluralaner | Bravecto® PLUS (Merck) | X |
| Xo | Xw | Xt | Xu |
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Eprinomectin + praziquantel | CENTRAGARD® (Boehringer Ingelheim) | X |
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| Xi | Xe | X4 |
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Selamectin | Revolution®, Paradyne® (Zoetis), Revolt™ (Aurora), Senergy™ (Virbac), Selarid™ (Norbrook) | X |
| X1 |
| Xi | Xe |
| Xv | |||
Selamectin + sarolaner | Revolution® Plus (Zoetis) | X |
| X1 | X3 | Xi | Xe |
| Xv | |||
PREVENTIVES FOR FERRETS (monthly spot-on) | Dirofilaria immitis | Other Parasites Treated in Addition to Heartworm | ||||||||||
Tissue Stages (Larvae) | Circulating Microfilariae | Fleas | Ticks | Hookworms | Roundworms | Tapeworms | Ear Mites | |||||
Drug | Trade Name(s) | |||||||||||
Moxidectin + imidacloprid | Advantage Multi® (Elanco) | X |
| Xo |
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a - Ancylostoma caninum, Uncinaria stenocephala, A. braziliense); b - Ascarids (Toxocara canis, Toxascaris leonina); c - Adult Ancylostoma caninum; d - Trichuris vulpis; e- Toxocara cati; f - Taenia pisiformis, Echinococcus multilocularis, E. granulosus, Dipylidium caninum; g - Adult & immature hookworms (Ancylostoma tubaeforme, A. braziliense); h - D. caninum, T. pisiformis; i - Adult Ancylostoma tubaeforme; j - Prevents development of flea eggs; does not kill adult fleas; k - Prevention and control of flea populations (Ctenocephalides felis); l - Treatment of flea infestations (C. felis and C. canis); m - Treatment of tick infestations, with immediate & persistent tick killing activity for 5 weeks against Ixodes hexagonus, I. ricinus, Rhipicephalus sanguineus & for 4 weeks against Dermacentor reticulatus; n - A. caninum L4 larvae, immature adults (L5) and adults; U. stenocephala adults; o - Kills adult fleas; prevention & treatment of flea infestations (C. felis); p - Larval and adult A. caninum & U. stenocephala; q - Adult, immature adult, & fourth-stage larvae (L4) of A. caninum and U. stenocephala; r - Adult T. leonina & adult & L4 of T. canis; s - Sarcoptes scabiei var. canis; t - Adult, immature adult, & L4 of A. tubaeforme; u - Adult, immature adult, & L4 of T. cati; v - Otodectes cynotis; w - Control of tick infestations due to I. scapularis, D. variabilis; x - Adult and L4 A. tubaeforme, adult A. braziliense; y - Adult and L4 T. cati; z - Adult D. caninum, E. multilocularis; 1 - Kills adult fleas & prevents flea eggs from hatching for 1 month; prevention & control of C. felis infestation; 2 - Control of tick infestations due to D. variabilis; 3 - Control of tick infestations due to I. scapularis, A. maculatum, D. variabilis; 4 - Adult D. caninum and E. multilocularis.</p</p</p</p</p
Feline Preventives
NAME | HEARTWORMS | ROUNDWORMS | HOOKWORMS | FLEAS | TICKS | EARMITES | TAPES | COMPANY | ACIVE INGREDIENT |
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INTERCEPTOR | X | X | X | ELANCO | MILBEMYCIN OXIME | ||||
HEARTGARD | X | X | BI | IVERMECTIN | |||||
BRAVECTO PLUS | X | X | X | X | X | X | MERCK | MOXIDECTIN | |
REVOLUTION | X | X | X | X | X | X | ZOETIS | SELAMECTIN | |
REVOLUTION PLUS | X | X | X | X | X | X | ZOETIS | SELAMECTIN | |
REVOLT | X | X | X | X | X | X | AURORA | SELAMECTIN | |
SELARID | X | X | X | X | X | X | NORBROOK | SELAMECTIN | |
CENTRAGARD | X | X | X | X | BI | EPRINOMECTIN | |||
MILBEGARD | X | X | X | CEVA | MILBEMYCIN OXIME | ||||
ADVANTAGE MULTI | X | X | X | X | X | ELANCO | MOXIDECTIN | ||
STONGHOLD | X | X | X | X | X | X | ZOETIS | SELAMECTIN | |
SENERGY | X | X | X | X | X | VIRBAC | SELAMECTIN | ||
MILBEHART | X | X | X | VIRBAC | MILBEMYCIN OXIME | ||||
IMOXI | X | X | X | X | X | X | VETOQUINOL | MOXIDECTIN |