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Heartworm Preventives

The American Heartworm Society recommends year-round administration of medications approved by the US Food and Drug Administration (FDA) to prevent heartworm infection. Currently available preventives are listed below; as new products become available, updates will be posted at heartwormsociety.org. Consult the appropriate manufacturer for minimum age/weight, use during breeding/lactation, or other health requirements for product usage.

Scroll down for feline and ferret preventives.

Preventives for Dogs

 Dirofilaria immitisOther Parasites Treated in Addition to Heartworm
DrugTrade Name(s)Tissue Stages (Larvae)Circulating MicrofilariaeFleasTicksHookwormsRoundwormsWhipwormsTapewormsEar MitesSarcoptic Mange Mites
Oral Administration (monthly tablets and chews)
Ivermectin HEARTGARD® (Boehringer Ingelheim) X                  
Ivermectin + pyrantel pamoate HEARTGARD® Plus (Boehringer Ingelheim), Iverhart Plus® (Virbac), Tri-Heart® Plus (Merck) X       Xa Xb        
Ivermectin + pyrantel pamoate + praziquantel Iverhart Max® (Virbac) X       Xa Xb   Xh    
Milbemycin oxime Interceptor® (Elanco) , MilbeGuard® (Ceva) X       Xc Xb Xd      
Milbemycin oxime + praziquantel Interceptor®Plus (Elanco) X       Xc Xb Xd Xf    
Milbemycin oxime + lufenuron Sentinel® (Merck) X   Xj   Xc Xb Xd      
Milbemycin oxime + lufenuron + praziquantel Sentinel® Spectrum® (Merck) X   Xk   Xc Xb Xd Xf    
Milbemycin oxime + spinosad Trifexis® (Elanco) X   Xo   Xc Xb Xd      
Moxidectin +

Afoxolaner + Pyrantel

NEXGARD® PLUS (Boehringer Ingelheim) X   Xo X7 Xa Xb        
Moxidectin + sarolaner + pyrantel pamoate Simparica® Trio (Zoetis) X   Xl Xm Xn Xb        
Injectable Administration (every 6 or 12 months)
Moxidectin ProHeart®6 (Zoetis), ProHeart®12 (Zoetis) X       Xp          
Topical Administration (monthly spot-on)
Moxidectin + imidacloprid Advantage Multi® (Elanco), IMOXI™ (Vetoquinol USA), PARASEDGETM Multi (Virbac), Midamox™ (Norbrook) X X Xo   Xq Xr Xd     Xs

Selamectin

Revolution® (Zoetis), Paradyne®(Vethical) , Senergy™ (Virbac) , Selarid™ (Norbrook) , Revolt™ (Aurora) X   X1 X2         Xv Xs

Preventives for Cats

 Dirofilaria immitisOther Parasites Treated in Addition to Heartworm
DrugTrade Name(s)Tissue Stages (Larvae)Circulating MicrofilariaeFleasTicksHookwormsRoundwormsTapewormsEar Mites
Oral Administration (monthly tablets and chews)
Ivermectin HEARTGARD® (Boehringer Ingelheim) X       Xg      
Milbemycin oxime Interceptor® (Elanco), MilbeGuard (Ceva) X       Xc Xe    
Topical Administration (monthly spot-on; Bravecto PLUS is every 2 months)
Moxidectin + imidacloprid Advantage Multi® (Elanco), IMOXI™ (Vetoquinol USA), PARASEDGETM Multi (Virbac), Midamox™ (Norbrook) X   Xo   Xt Xu   Xv
Moxidectin + fluralaner Bravecto®PLUS (Merck) X   Xo Xw Xt Xu    
Eprinomectin + praziquantel CENTRAGARD® (Boehringer Ingelheim) X       Xi Xe X4  
Esafoxolaner + eprinomectin + praziquantel NEXGARD® COMBO X   Xo X5 Xg Xe X6  
Selamectin Revolution®, Paradyne® (Vethical), Revolt™ (Aurora), Senergy™ (Virbac), Selarid™ (Norbrook) X   X1   Xi Xe   Xv
Selamectin + sarolaner Revolution®Plus (Zoetis) X   X1 X3 Xi Xe   Xv

Preventives for Ferrets

 Dirofilaria immitisOther Parasites Treated in Addition to Heartworm
DrugTrade Name(s)Tissue Stages (Larvae)Circulating MicrofilariaeFleasTicksHookwormsRoundwormsTapewormsEar Mites
Moxidectin + imidacloprid Advantage Multi® (Elanco) X   Xo          

a - Ancylostoma caninum, Uncinaria stenocephala, A. braziliense; b - Ascarids (Toxocara canis, Toxascaris leonina); c - Adult Ancylostoma caninum; d - Trichuris vulpis; e- Toxocara cati; f - Taenia pisiformis, Echinococcus multilocularis, E. granulosus, Dipylidium caninum; g - Adult & immature hookworms (Ancylostoma tubaeforme, A. braziliense); h - D. caninum, T. pisiformis; i - Adult Ancylostoma tubaeforme; j - Prevents development of flea eggs; does not kill adult fleas; k - Prevention and control of flea populations (Ctenocephalides felis); l - Treatment of flea infestations (C. felis and C. canis); m - Treatment of tick infestations, with immediate & persistent tick killing activity for 5 weeks against Ixodes hexagonus, I. ricinus, Rhipicephalus sanguineus & for 4 weeks against Dermacentor reticulatus; n - A. caninum L4 larvae, immature adults (L5) and adults; U. stenocephala adults; o - Kills adult fleas; prevention & treatment of flea infestations (C. felis); p - Larval and adult A. caninum & U. stenocephala; q - Adult, immature adult, & fourth-stage larvae (L4) of A. caninum and U. stenocephala; r - Adult T. leonina & adult & L4 of T. canis; s - Sarcoptes scabiei var. canis; t - Adult, immature adult, & L4 of A. tubaeforme; u - Adult, immature adult, & L4 of T. cati; v - Otodectes cynotis; w - Control of tick infestations due to I. scapularis, D. variabilis, Haemaphysalis longicornis; x - Adult and L4 A. tubaeforme, adult A. braziliense; y - Adult and L4 T. cati; z - Adult D. caninum, E. multilocularis; 1 - Kills adult fleas & prevents flea eggs from hatching for 1 month; prevention & control of C. felis infestation; 2 - Control of tick infestations due to D. variabilis; 3 - Control of tick infestations due to I. scapularis, A. maculatum, D. variabilis; 4 - Adult D. caninum and E. multilocularis; 5 - Treatment and control of I. scapularis, R. sanguineus, D. variabilis, andA. americanum infestations for one month in dogs and puppies 8 weeks of age and older, weighing >4 pounds; 6 - D. caninum; 7 - Treatment and control of I. scapularis, R. sanguineous, D. variabilis, and A. americanum infestations for one month.

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The days are getting shorter, the nights are cooler, leaves are starting to turn, and football season is here. But that doesn’t mean your clients can forget about protecting their pets from heartworms.

To keep this message front and center with your clients, we’re sharing a set of new posters you can print OR post on your Facebook or Instagram page.

  • To save or print a poster, just click on the image below, then click on the “download” button and save the PDF file.
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