Heartworm Preventives

The American Heartworm Society recommends year-round administration of medications approved by the US Food and Drug Administration (FDA) to prevent heartworm infection. Currently available preventives are listed below; as new products become available, updates will be posted at heartwormsociety.org. Consult the appropriate manufacturer for minimum age/weight, use during breeding/lactation, or other health requirements for product usage.

PREVENTIVES FOR DOGS

Dirofilaria immitis

Other Parasites Treated in Addition to Heartworm

Tissue Stages (Larvae)

Circulating Microfilariae

Fleas

Ticks

Hookworms

Roundworms

Whipworms

Tapeworms

Ear Mites

Sarcoptic Mange Mites

Drug

Trade Name(s)

Oral Administration (monthly tablets and chews)

Ivermectin

HEARTGARD® (Boehringer Ingelheim)

X

 

 

 

 

 

 

 

 

 

 

Ivermectin + pyrantel pamoate

HEARTGARD® Plus (Boehringer Ingelheim)

X

 

 

 

Xa

Xb

 

 

 

 

Iverhart Plus® (Virbac)

X

 

 

 

Xa

Xb

 

 

 

 

Tri-Heart® Plus (Merck)

X

 

 

 

Xa

Xb

 

 

 

 

Ivermectin + pyrantel pamoate + praziquantel

Iverhart Max® (Virbac)

X

 

 

 

Xa

Xb

 

Xh

 

 

Milbemycin oxime

Interceptor® (Elanco)MilbeGuard® (Ceva)

X

 

 

 

Xc

Xb

Xd

 

 

 

Milbemycin oxime + praziquantel

Interceptor® Plus (Elanco)

X

 

 

 

Xc

Xb

Xd

Xf

 

 

Milbemycin oxime + lufenuron

Sentinel® (Merck)

X

 

Xj

 

Xc

Xb

Xd

 

 

 

Milbemycin oxime + lufenuron + praziquantel

Sentinel® Spectrum® (Merck)

X

 

Xk

 

Xc

Xb

Xd

Xf

 

 

Milbemycin oxime + spinosad

Trifexis® (Elanco)

X

 

Xo

 

Xc

Xb

Xd

 

 

 

Moxidectin + sarolaner + pyrantel pamoate

Simparica® Trio (Zoetis)

X

 

Xl

Xm

Xn

Xb

 

 

 

 

Injectable Administration (every 6 or 12 months)

Moxidectin

ProHeart® 6 (Zoetis), ProHeart® 12 (Zoetis)

X

 

 

 

Xp

 

 

 

 

 

Topical Administration (monthly spot-on)

Moxidectin + imidacloprid

Advantage Multi® (Elanco), IMOXI(Vetoquinol USA)

X

X

Xo

 

Xq

Xr

Xd

 

 

Xs

Selamectin

Revolution® (Zoetis), Paradyne® (Zoetis), Senergy(Virbac), Selarid(Norbrook), Revolt(Aurora)

X

 

X1

X2

 

 

 

 

Xv

Xs

PREVENTIVES FOR CATS

Dirofilaria immitis

Other Parasites Treated in Addition to Heartworm

Tissue Stages (Larvae)

Circulating Microfilariae

Fleas

Ticks

Hookworms

Roundworms

Tapeworms

Ear Mites

Drug

Trade Name(s)

Oral Administration (monthly tablets and chews)

Ivermectin

HEARTGARD® (Boehringer Ingelheim)

X

 

 

 

Xg

 

 

 

Milbemycin oxime

Interceptor® (Elanco)MilbeGuard (Ceva)

X

 

 

 

Xc

Xe

 

 

Topical Administrations (monthly spot-on; Bravecto PLUS is every 2 months)

Moxidectin + imidacloprid

Advantage Multi® (Elanco), IMOXI™ (Vetoquinol USA)

X

 

Xo

 

Xt

Xu

 

Xv

Moxidectin + fluralaner

Bravecto® PLUS (Merck)

X

 

Xo

Xw

Xt

Xu

 

 

Eprinomectin + praziquantel

CENTRAGARD® (Boehringer Ingelheim)

X

 

 

 

Xi

Xe

X4

 

Selamectin

Revolution®, Paradyne® (Zoetis), Revolt(Aurora), Senergy(Virbac), Selarid(Norbrook)

X

 

X1

 

Xi

Xe

 

Xv

Selamectin + sarolaner

Revolution® Plus (Zoetis)

X

 

X1

X3

Xi

Xe

 

Xv

PREVENTIVES FOR FERRETS

(monthly spot-on)

Dirofilaria immitis

Other Parasites Treated in Addition to Heartworm

Tissue Stages (Larvae)

Circulating Microfilariae

Fleas

Ticks

Hookworms

Roundworms

Tapeworms

Ear Mites

Drug

Trade Name(s)

Moxidectin + imidacloprid

Advantage Multi® (Elanco)

X

 

Xo

 

 

 

 

 

a - Ancylostoma caninum, Uncinaria stenocephala, A. braziliense); b - Ascarids (Toxocara canis, Toxascaris leonina); c - Adult Ancylostoma caninum; d - Trichuris vulpis; e- Toxocara cati; f - Taenia pisiformis, Echinococcus multilocularis, E. granulosus, Dipylidium caninum; g - Adult & immature hookworms (Ancylostoma tubaeforme, A. braziliense); h - D. caninum, T. pisiformis; i - Adult Ancylostoma tubaeforme; j - Prevents development of flea eggs; does not kill adult fleas; k - Prevention and control of flea populations (Ctenocephalides felis); l - Treatment of flea infestations (C. felis and C. canis); m - Treatment of tick infestations, with immediate & persistent tick killing activity for 5 weeks against Ixodes hexagonus, I. ricinus, Rhipicephalus sanguineus & for 4 weeks against Dermacentor reticulatus; n - A. caninum L4 larvae, immature adults (L5) and adults; U. stenocephala adults; o - Kills adult fleas; prevention & treatment of flea infestations (C. felis); p - Larval and adult A. caninum & U. stenocephala; q - Adult, immature adult, & fourth-stage larvae (L4) of A. caninum and U. stenocephala; r - Adult T. leonina & adult & L4 of T. canis; s - Sarcoptes scabiei var. canis; t - Adult, immature adult, & L4 of A. tubaeforme; u - Adult, immature adult, & L4 of T. cati; v - Otodectes cynotis; w - Control of tick infestations due to I. scapularis, D. variabilis; x - Adult and L4 A. tubaeforme, adult A. braziliense; y - Adult and L4 T. cati; z - Adult D. caninum, E. multilocularis; 1 - Kills adult fleas & prevents flea eggs from hatching for 1 month; prevention & control of C. felis infestation; 2 - Control of tick infestations due to D. variabilis; 3 - Control of tick infestations due to I. scapularis, A. maculatum, D. variabilis; 4 - Adult D. caninum and E. multilocularis.</p</p</p</p</p